NEJM This Week — October 22, 2020
30 min
Featuring articles on dasatinib–blinatumomab in Ph-positive ALL, an anti–Siglec-8 antibody in gastritis and duodenitis, inhaled molgramostim therapy in autoimmune pulmonary alveolar proteinosis, treating Middle East Respiratory Syndrome, fibroblasts in rheumatoid arthritis, and how can we bridge the partisan divide and conquer Covid; a review article on sensory ganglionopathy; a case report of a man with abdominal pain, joint swelling, and skin lesions; and Perspective articles on whether the elections can end the health reform stalemate, on insurance coverage after job loss, on redoubling efforts to help Americans quit smoking, and on taking back our voices.
Streetwise Hebrew
Streetwise Hebrew
TLV1 Studios
#315 Sarah Sings a Blissful Song
In Hebrew, שירה means singing. It can also be used to mean poetry. It depends on the context. On this episode, Guy reviews the words that stem from the root ש/י/ר and several well-known phrases that make use of them. Check Out the All-Hebrew Episode on Patreon New Words and Expressions: Nurit – Buttercup – נורית Agav – Speaking of, apropos – אגב Shira – Singing, Poetry – שירה Shira be-tsibur – Singalong – שירה בציבור Ha-cohenet ha-gdola – The high priestess – הכוהנת הגדולה Meshorer, meshoreret – Poet – משורר, משוררת Le-ma Hitkaven Ha-meshorer? – What did the poet mean? – ?למה התכוון המשורר Festival Ha-Zemer Ve-ha-pizmon Ha-israeli – The Israel song festival – פסטיבל הזמר והפזמון הישראלי Zemer – A song – זמר Pizmon – The chorus section of a song – פזמון “Ve-ha-zamar yezamer” – And the singer will sing – והזמר יזמר Zamar, zameret – Singer – זמר, זמרת Hu yezamer ba-chakira – He’s going to sing like a bird in the interrogation – הוא יזמר בחקירה Machazemer (pl. machazot zemer) – A musical (machaze+zemer) – מחזמר Mizmor – Hymn, chant – מזמור Zamrir – Jingle – זמריר Playlist and Clips: Nurit Galron – Ma Yihye Be-sofenu (lyrics) Sarale Sharon – Shira be-tsibur Eliyahu Ha-cohen’s post Einat Saruf – Shira be-tsibur Leah Goldberg – Mechora Sheli Le-ma Hitkaven Ha-meshorer Festival Ha-Zemer Ve-ha-pizmon Ha-israeli The Israel Song Festival (Wikipedia) The Revivo Project – Od Yom Yavo (lyrics) Hanny Nahmias – Dvarim She-oti Mesamchim (lyrics) Shlishiyat Af-Ozen-Garon – Sarah shara shir same’ach (lyrics) Guy’s playlists Ep. 219 (negina)
17 min
Bedside Rounds
Bedside Rounds
Adam Rodman, MD, MPH, FACP
59 - Cry of the Suffering Organs
Diagnosis is arguably the most important job of a physician. But what does it actually mean to make a diagnosis? In this episode, we’ll explore this question by tracking the development of the “classical” model of diagnosis and pathological anatomy and discussing three cases over three hundred years. Along the way, we’ll ponder the concept of the lesion, iatromechanistic theories of the human machine, the birth of the International Classification of Diseases, and the rise and decline of the autopsy. You can sign up for the iMED Digital Education conference at cmeregistration.hms.harvard.edu/digitaleducation. Sources: * Hooper R, The Physician’s Vade-Mecum: Containing the Symptoms, Causes, Diagnosis, Prognosis and Treatment of Diseases. 1812. * Holdman L et al, The Value of the Autopsy in Three Medical Eras. N Engl J Med 1983; 308:1000-1005. * Cabot RC et al. CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITALANTE-MORTEM AND POST-MORTEM RECORDS AS USED IN WEEKLY CLINICO-PATHOLOGICAL EXERCISES. Case 9431. Boston Med Surg J 1923; 189:595-599. * Shojania KG and Burton EC, The Vanishing Nonforensic Autopsy. N Engl J Med 2008; 358:873-875 * Morgagni GB. The seats and causes of diseases investigated by anatomy in five books, containing a great variety of dissections, with remarks. To which are added ... copious indexes. 1769. Retrieved online: https://openlibrary.org/works/OL15821973W/The_seats_and_causes_of_diseases_investigated_by_anatomy * Castiglioni A, GB Morgagni and the Anatomico-pathological Conception of the Clinical. Proceedings of the Royal Society of Medicine, November 7, 1934. * Thiene G, Padua University: The role it has played in the History of Medicine and Cardiology and its position today. European Heart Journal, Volume 30, Issue 6, March 2009, Pages 629–635. * Zampieri F et al, Origin and development of modern medicine at the University of Padua and the role of the “Serenissima” Republic of Venice. Glob Cardiol Sci Pract. 2013; 2013(2): 149–162. * Conner, Annastasia (2017) "Galen’s Analogy: Animal Experimentation and Anatomy in the Second Century C.E.," Anthós: Vol. 8: Iss. 1, Article 9. * Zampieri F et al. The clinico-pathological conference, based upon Giovanni Battista Morgagni's legacy, remains of fundamental importance even in the era of the vanishing autopsy. Virchows Arch. 2015 Sep;467(3):249-54. * Ghosh SK, Giovanni Battista Morgagni (1682-1771): father of pathologic anatomy and pioneer of modern medicine. Anat Sci Int. 2017 Jun;92(3):305-312. * O’Neal JC, Auenbrugger, Corvisart, and the Perception of Disease. Eighteenth-Century Studies Vol. 31, No. 4, The Mind/Body Problem (Summer, 1998), pp. 473-489 * Brown TM, THE COLLEGE OF PHYSICIANS AND THE ACCEPTANCE OF IATROMECHANISM IN ENGLAND, 1665-1695. Bulletin of the History of Medicine Vol. 44, No. 1 (JANUARY-FEBRUARY 1970), pp. 12-30 * Roos AM, Luminaries in Medicine: Richard Mead, James Gibbs, and Solar and Lunar Effects on the Human Body in Early Modern England. Bulletin of the History of Medicine Vol. 74, No. 3 (Fall 2000), pp. 433-457 (25 pages) * Frith J, History of Tuberculosis. Part 1 – Phthisis, consumption and the White Plague. JMVH. 2014; 22(2). * World Health Organization, History of the development of the ICD. https://www.who.int/classifications/icd/en/HistoryOfICD.pdf * Laennec RTH, A treatise on diseases of the chest and on mediate auscultation. 1834. Retrieved from: https://archive.org/details/b21987002. * Marinker M, Why make people patients? J Med Ethics. 1975 Jul; 1(2): 81–84. * King LS, Medical Thinking: A Historical Preface. Princeton University Press, 2016.
43 min
Charting Pediatrics
Charting Pediatrics
Children's Hospital Colorado
Rebroadcast: COVID-19 Taking Care of Adult Patients During the Pandemic with Aaron Manning, MD and Steven Humphrey, MD (S3:E49)
Join us for our bi-weekly COVID-19 Virtual Provider Town Hall series featuring updates from Children's Infectious Diseases team and live Q&A: https://bit.ly/3qiKGzV - our next Town Hall is on Thursday, December 3, 2020 from 6-7:30p.m. MST. With COVID-19 cases surging across the United States and Europe we hope this episode is a timely refresher for any of our pediatric colleagues who are being called into service to care for adult patients. In this rebroadcast of S3:E49, we have a case discussion around functional and high-yield adult medicine topics that might be useful for pediatricians helping to care for adult patients in the middle of the pandemic. You can go back and listen to our previous coverage on the COVID-19 Pandemic on Season 3 & 4 of the podcast. Today we are fortunate to be joined by Dr. Aaron Manning and Dr. Steven Humphrey. Steven is a pediatric hospitalist at Children’s Hospital Colorado and Instructor of Pediatrics at the University of Colorado School of Medicine. Aaron is also a pediatric hospitalist at Children’s Colorado and is Assistant Professor of Hospital Medicine at the University of Colorado School of Medicine. * POPCoRN (Pediatric Overflow Planning Contingency Response Network): https://www.popcornetwork.org/. This site is a multi-institutional collaboration that was created during the COVID-19 pandemic as a vehicle for optimizing adult care in pediatric environments. It contains many “one-pagers” which review the management of a variety of common adult conditions, links to adult protocols shared by various institutions, and recommendations regarding care of patients with COVID-19 among others. * Adult medicine guidebooks: Several organizations have made available their adult medicine guidebooks free of charge. * UCSF Department of Medicine Hospitalist Handbook (currently free in the Apple and Google App Stores) * MGH Resource Guide for Commonly-Encountered Inpatient Topics (available via the POPCoRN website) * Society for Hospitalist Medicine: Non-Hospitalist Onboarding. This resource offers a step by step guide to preparing non-hospitalists for the inpatient management of adult care (available via the POPCoRN website) * University of Pennsylvania Hospitalists Primer. A resource meant to prepare non-hospitalists for the care of hospitalized adults (http://pennhspprimer.com/) Do you have thoughts about today's episode or suggestions for a future topic? Write to us, chartingpediatrics@childrenscolorado.org
40 min
BrainWaves: A Neurology Podcast
BrainWaves: A Neurology Podcast
Jim Siegler, MD | Neurologist | Father | Friend of dogs
#174 The mental status
The mental status exam is a keystone of the neurologic assessment. Dr. Andrea Casher (Cooper University Hospital) builds upon this metaphor in our program this week. Making a special appearance is US President Donald Trump, who underwent a mental status exam and recounts his experience. Produced by James E. Siegler and Andrea Casher. Music courtesy of Unheard Music Concepts, Purple Planet Music, Lee Rosevere, and Scott Holmes. The opening theme was composed by Jimothy Dalton. Sound effects by Mike Koenig and Daniel Simion. Unless otherwise mentioned in the podcast, no competing financial interests exist in the content of this episode. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast. REFERENCES * Tombaugh TN and McIntyre NJ. The mini-mental state examination: a comprehensive review. J Am Geriatr Soc. 1992;40:922-35. * Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL and Chertkow H. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695-9. * Dong Y, Sharma VK, Chan BP, Venketasubramanian N, Teoh HL, Seet RC, Tanicala S, Chan YH and Chen C. The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke. Journal of the neurological sciences. 2010;299:15-8. * Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, Cappa SF, Ogar JM, Rohrer JD, Black S, Boeve BF, Manes F, Dronkers NF, Vandenberghe R, Rascovsky K, Patterson K, Miller BL, Knopman DS, Hodges JR, Mesulam MM and Grossman M. Classification of primary progressive aphasia and its variants. Neurology. 2011;76:1006-14. * Ng KP, Chiew HJ, Lim L, Rosa-Neto P, Kandiah N and Gauthier S. The influence of language and culture on cognitive assessment tools in the diagnosis of early cognitive impairment and dementia. Expert review of neurotherapeutics. 2018;18:859-869. * Rabinovitz B, Jaywant A and Fridman CB. Neuropsychological functioning in severe acute respiratory disorders caused by the coronavirus: implications for the current COVID-19 pandemic. Clin Neuropsychol. 2020:1-27.
30 min
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