The Pastore Podcast
On "Calories In Calories Out" for Weight Loss
Jan 10, 2020 · 1 hr 21 min
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Dr. Pastore and Lexie are back and kicking off 2020 with a popular “New Years Resolution” health topic - calories in vs. calories out.

When it comes to weight loss, there are many factors people typically don’t take into consideration when calculating both the “calories in” and “calories out” portions of the equation.

They discuss:

  • What a calorie is
  • Thermodynamics
  • Macronutrients and their thermogenic effect
  • A protein study on the thermogenic effect of pork vs other meats
  • Gene variances that make it more difficult for some of the population to lose weight compared to others
    • COMT-RS4680-GG - likely to overeat/never feel satiated gene
    • SLC2A2-RS5400-TC or GT - “sweet tooth” gene
  • The negative metabolic effects of yo-yo dieting
  • The negative metabolic effects of losing a significant amount of weight in a short period of time
  • How food intolerances affect both “calories in” and “calories out”
  • Why “adrenal fatigue” is NOT recognized as an official diagnosis in the medical community


Articles mentioned:

Thermodynamics of weight loss diets


"A calorie is a calorie" violates the second law of thermodynamics


Effects of Eating Fresh Lean Pork on Cardiometabolic Health Parameters


Biggest Loser Metabolism Study


Harvard Magazine - Are All Calories Equal?

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