#133 – Manolis Kellis: Biology of Disease
2 hr 40 min

Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors:
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EPISODE LINKS:
Manolis Website: http://web.mit.edu/manoli/
Manolis Twitter: https://twitter.com/manoliskellis
Manolis YouTube: https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA
Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis

PODCAST INFO:
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YouTube Clips: https://youtube.com/lexclips

SUPPORT & CONNECT:
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– Medium: https://medium.com/@lexfridman

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
00:00 – Introduction
08:05 – Molecular basis for human disease
32:04 – Deadliest diseases
37:47 – Genetic component of diseases
46:38 – Genetic understanding of disease
1:02:25 – Unified theory of human disease
1:08:26 – Genome circuitry
1:33:29 – CRISPR
1:45:06 – Mitochondria
1:53:10 – Future of biology research
2:22:46 – The genetic circuitry of disease

The Peter Attia Drive
The Peter Attia Drive
Peter Attia, MD
#139 - Kristin Neff, Ph.D.: The power of self-compassion
Kristin Neff is a Professor of Educational Psychology at the University of Texas, author, and a leading expert on mindful self-compassion. In this episode, she shares how developing a self-compassion and mindfulness practice was the most effective tool for relieving her own suffering, and provides strategies and tactics to improve self-compassion and well-being. We discuss: * The life crisis that turned Kristin to mindfulness and self-compassion (3:30); * How mindful self-compassion relieved Kristin’s feelings of self-judgement, and the psychology that says we all have the capacity for self-compassion (9:45); * Peter’s history of self-criticism and his personal practice of self-compassion (17:15); * The problem with prioritizing self-esteem over self-compassion, and how self-compassion produces a more stable version of self-worth (20:15); * An argument for self-compassion over self-criticism for optimizing performance (26:15); * How and when to introduce self-compassion to children (31:45); * Learning her son had autism—a personal story of how Kristin used mindfulness and self-compassion (36:45); * Self-compassion for cases of childhood trauma, PTSD, and overcoming a “fear of compassion” (44:00); * The relationship between self-compassion and physical health (49:30); * Distinguishing between self-compassion and self-pity, and the three necessary components self-compassion (52:30); * Why self-criticism comes from a desire to be safe, the circular pattern of self-judgment, and self-compassion as the ultimate motivator (55:45); * Potential role of a self-compassion practice for addiction and other maladaptive behaviors (58:45); * Clinical applications and practical uses of self-compassion (1:01:30); * Why you don’t need to meditate to learn mindfulness and self-compassion (1:04:45); * Kristin’s personal meditation practice (1:08:40); * Resources for learning self-compassion (1:11:45); and * More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/kristinneff Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on _Faceboo__k_ | _Twitter_ | _Instagram_.
1 hr 17 min
The Art of Manliness
The Art of Manliness
The Art of Manliness
#665: How Childhood Shapes Adulthood
Ask an adult, especially if they're struggling in life, what caused them to end up the way they did, and they might cite certain factors from their childhood, like having a mother that was too cold. The problem here, of course, is that memories change over time, and narratives about the past develop to fit one's current situation. My guests today work on the kind of research that corrects this problem to figure out how aspects of childhood truly affect adulthood, by studying humans from the time they're babies through middle age and beyond. Their names are Jay Belsky and Terrie Moffitt, and they're professors of human development, and two of the four contributors to The Origins of You: How Childhood Shapes Later Life. To begin our conversation, Jay and Terrie discuss the longitudinal studies they and their colleagues have used to track people over decades of their lives, and how aggressiveness and shyness in childhood end up impacting adulthood. We then discuss the limitations of the famous marshmallow experiment, and what these more expansive longitudinal studies have shown about the importance of self-control in achieving a successful adulthood. We unpack whether the negative outcomes associated with being bullied in childhood are inevitable, who's most likely to become a bully, and who's most likely to be bullied (which as it turns out, isn't a matter of being fat or wearing glasses). We discuss how children who act out in childhood, but avoid making certain mistakes in adolescence, can still turn out okay, and why you probably shouldn't worry about children who were good kids, but get into a little trouble in their teen years. We also dig into the impact that childcare has on kids, and the role that genes play in development. We end our conversation with some allowance-related ideas for cultivating greater self-control in your kids.  Get the show notes at aom.is/childhood. See omnystudio.com/listener for privacy information.
55 min
Policy, Guns & Money
Policy, Guns & Money
The Australian Strategic Policy Institute
US election disinformation, China’s soft power, data digitization and preservation
Ariel Bogle speaks to Dr Kate Starbird, Associate Professor at the University of Washington and researcher at the Election Integrity Partnership. They discuss the growing challenges for social media companies in moderating online disinformation and misinformation in the context of the US elections and President Trump’s dispute of the election results. Michael Shoebridge speaks to Rowan Callick, double Walkley Award winning journalist and author, about his recent report for the Centre for Independent Studies titled ‘The Elite Embrace’. They discuss how the Chinese party-state influences key elites in Australia and around the world, and the ten talking points to look out for in Beijing’s engagement with foreign elites. Anne Lyons speaks to David Fricker, Director-General of the National Archives of Australia, about the organisation’s recently announced plans to digitise data, including over 650,000 Second World War service records and over 30,000 at-risk audiovisual records. They discuss the importance of reliable data and why human rights are in the conversation around data access. Mentioned in this episode: https://www.eipartnership.net/ https://www.cis.org.au/publications/occasional-papers/the-elite-embrace/ Guests: Ariel Bogle: @arielbogle (Twitter) Dr Kate Starbird: https://www.hcde.washington.edu/starbird Michael Shoebridge: https://www.aspi.org.au/bio/michael-shoebridge Rowan Callick: http://rowancallick.com/ Anne Lyons: https://www.aspi.org.au/bio/anne-lyons David Fricker: https://www.naa.gov.au/about-us/our-organisation/senior-executives/david-fricker-cdoal-bacomp-gaicd Music: "She No Dull Beat" by 'Nana Kwabena' via the YouTube Audio Library. Image: pexels.com
53 min
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