#133 – Manolis Kellis: Biology of Disease
2 hr 40 min

Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors:
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EPISODE LINKS:
Manolis Website: http://web.mit.edu/manoli/
Manolis Twitter: https://twitter.com/manoliskellis
Manolis YouTube: https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA
Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis

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OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
00:00 – Introduction
08:05 – Molecular basis for human disease
32:04 – Deadliest diseases
37:47 – Genetic component of diseases
46:38 – Genetic understanding of disease
1:02:25 – Unified theory of human disease
1:08:26 – Genome circuitry
1:33:29 – CRISPR
1:45:06 – Mitochondria
1:53:10 – Future of biology research
2:22:46 – The genetic circuitry of disease

The Art of Manliness
The Art of Manliness
The Art of Manliness
#664: The Masters of the Art of War
Looked at from the heat of combat, war can seem disorganized and chaotic. But overarching the conflict is typically some kind of thoughtful, well-ordered, even scientific strategy that is influencing when, where, how, and why dueling forces have met. My guest today will introduce us to a few of the military philosophers and tacticians who made the most significant contributions to the art of strategy over the last couple millenia. His name is Andrew Wilson, and he's a professor at the Naval War College, as well as the lecturer of the Great Courses course, Masters of War: History's Greatest Strategic Thinkers. We begin our conversation with a brief overview of what martial strategy is, why civilians should study it, and how the contrast between generals Eisenhower and Patton delineate the difference between strategy and operations. We then survey several of history's most influential war strategists, and the contexts in which their theories and doctrines were born. This tour includes a discussion of how Sun Tzu used The Art of War to argue that a new type of war in a new type of society required a new type of general who could process conflicts like a supercomputer, and a dive into how Carl von Clausewitz emphasized the importance of understanding how complexity, irrational passions, and creative genius underlay contemporary warfare. We end our conversation with how military strategy has or hasn’t changed in the 21st century. Get the show notes at aom.is/mastersofwar. See omnystudio.com/listener for privacy information.
50 min
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