#133 – Manolis Kellis: Biology of Disease
2 hr 40 min

Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors:
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EPISODE LINKS:
Manolis Website: http://web.mit.edu/manoli/
Manolis Twitter: https://twitter.com/manoliskellis
Manolis YouTube: https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA
Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis

PODCAST INFO:
Podcast website: https://lexfridman.com/podcast
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Spotify: https://spoti.fi/2nEwCF8
RSS: https://lexfridman.com/feed/podcast/
YouTube Full Episodes: https://youtube.com/lexfridman
YouTube Clips: https://youtube.com/lexclips

SUPPORT & CONNECT:
– Check out the sponsors above, it’s the best way to support this podcast
– Support on Patreon: https://www.patreon.com/lexfridman
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– Instagram: https://www.instagram.com/lexfridman
– LinkedIn: https://www.linkedin.com/in/lexfridman
– Facebook: https://www.facebook.com/LexFridmanPage
– Medium: https://medium.com/@lexfridman

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
00:00 – Introduction
08:05 – Molecular basis for human disease
32:04 – Deadliest diseases
37:47 – Genetic component of diseases
46:38 – Genetic understanding of disease
1:02:25 – Unified theory of human disease
1:08:26 – Genome circuitry
1:33:29 – CRISPR
1:45:06 – Mitochondria
1:53:10 – Future of biology research
2:22:46 – The genetic circuitry of disease

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas
Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas
Sean Carroll | Wondery
124 | Solo: How Time Travel Could and Should Work
Time! It doesn’t stop, psychological effects of being under lockdown notwithstanding. How we experience time depends on our situation, but time itself just marches forward. Unless, of course, it’s possible to travel to the past, as countless science-fiction scenarios have depicted. But does that really make sense? Couldn’t we then change the past, even so dramatically that our own existence would never have happened? In this solo podcast I talk about both the physics and fiction of time travel. I point out that it might be allowed by the laws of physics, and explain how that would work, but that we really don’t know. And I try to make sense of some of the less-sensible depictions of cinematic time travel. Coming up with a logical theory that could account for Back to the Future isn’t easy, but podcasting isn’t for the squeamish. Support Mindscape on Patreon. But wait, there’s more! I was contacted by Janna Levin, who we fondly remember from Episode 27. Janna moonlights as Chair and Director of Sciences at Pioneer Works, an institution dedicated to bringing together creative people in art and science. Like the rest of us, they’ve been looking for ways to offer more online content in these pandemic times, so we thought about ways to collaborate. Here’s what they came up with: artist Azikiwe Mohammed has created an animated video backdrop to this podcast episode. The visuals are trippy, colorful, and inspired by (without trying to directly illustrate) what I talk about in the episode. You can check out a brief write-up at the Pioneer Works site, or view the video directly below. https://www.youtube.com/watch?v=kHy1j4LiyGQ
2 hr 42 min
Steal This Beer
Steal This Beer
Steal This Beer
Episode 293 - Chris Herron & Adam Beauchamp, Creature Comforts Brewing
Episode 293 - Chris Herron & Adam Beauchamp, Creature Comforts Brewing Happy Monday, Thieves! Who doesn't love Fat Thor? This week we're glad to welcome Chris Herron and Adam Beauchamp of Creature Comforts Brewing in  Athens, GA (and coming soon to Los Angeles, CA). Chris is the CEO and Adam is the brewmaster of the rapidly growing brewery that has a lot of deep thoughts on the world of craft. Specifically you might remember an article that Chris wrote a few years back. It stuck in Augie's mind and so we spend a good amount of time talking about how craft has evolved, how the larger breweries are confusing the market and customers, and how the little guy can fight back.  Then we get to talk about the brewery's cameo in Avengers: Endgame and how that eventually led to them announcing a soon-to-open brewery in Los Angeles. It's cool to geek out when they mention the Russo Brothers. We sure did.  Justin hit us with some fun in the black glass, but USPS dropped the ball and the fellas of Creature Comforts weren't able to play along. Tune in here to hear all about it, and of course let us know what you think! ** As always, you can email your questions, complaints, whimpers, or whines to us at stealthisbeerpodcast@gmail.com. We read everything we get and we'll try to respond as quickly as we can. If not online, then on air. And THANKS! You can subscribe to STB on iTunes and PLEASE LEAVE US A REVIEW!!! Co-hosts: Augie Carton & John Holl Producer: Justin Kennedy Engineer: Brian Casse Music: "Abstract Concepts - What Up in the Streets" by Black Ant.
The Bottom Up Revolution
The Bottom Up Revolution
Strong Towns
Krista Fancher: Teaching Young People to Think Resiliently
It’s Member Week here at Strong Towns, and something our president, Chuck Marohn, shared on Monday is that Strong Towns members are some of the most civically engaged people we know. In a recent survey, over 50% said they’re volunteering in their communities. Nearly half said they had met with an elected official. 16% have actually run for office themselves! And nearly all of our members have shared Strong Towns articles and ideas with their neighbors. If you’re a member, thank you! We’re floored by all that you do and honored to get to play a small part in moving you to action. If you’re not a member and you’re looking at that list thinking, “Well, I volunteer in my community, I share Strong Towns articles, I work with my neighbors to improve my city…” Then it’s time you make your commitment official and join this movement. Visit strongtowns.org/membership to join today. ---- Today’s guest is Krista Fancher, a Strong Towns member who teaches at a unique high school program called the Innovation Diploma at the Mount Vernon School in Atlanta, Georgia. Their approach to learning is very hands-on and encourages entrepreneurship and innovation—exactly the sorts of skills young people need these days to grow into dedicated citizens who make their communities strong. Bottom-Up Revolution host and Program Director, Rachel Quednau, had the honor of working with some of her students this semester on a project where they explored housing issues and how to adapt existing buildings to create more housing opportunities. Krista is devoted to helping young people learn, grow and thrive. Whether you’ve got kids of your own or have the chance to work with young people as a coach, mentor, or just a doting aunt or uncle—we know you’ll learn from Krista’s perspective and see how important our young people are as we think about building strong towns for the future. At the end of the episode, we also take a moment to shout-out some of those 16% of Strong Towns members who recently ran for office and many who currently hold elected office. Additional Show Notes * Mount Vernon School - Innovation Diploma program * Evicted: Poverty and Profit in the American City by Matthew Desmond * Innovation Diploma Students’ Getting into Good Trouble Podcast * Send us your own voicemail about the small (or big) thing you’re doing to make your town stronger. Just record a voice memo on your phone and email it to rachel@strongtowns.org. * Subscribe to The Bottom-Up Revolution on iTunes, Google Podcasts, Podbean, or via RSS. * Support this show and our many other resources for helping your town grow stronger by becoming a member today.
23 min
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