This episode discussed two major concepts, the optimal blood pressure target for trauma patients and the use of vasopressors in trauma (WHAT!). We look at the use of permissive hypotension in trauma and discuss its applications and indications as well as its history. This of course is merely a prelude to our discussion of the use of pressors in trauma, which many of us know is true sacrilege... or is it? We examine the question through the lens of the AVERT-SHOCK trial and discuss this in-depth.