Weight loss is as simple as “calories in, calories out,” right? Or — gasp — could the reply guys be wrong!? This week, we dig in on the surprisingly complex science behind a seemingly simple calculation.

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• History of the Calorie in Nutrition
• Caloric Equivalents of Gained or Lost Weight
• The Foreign Policy of the Calorie
• Why the most popular rule of weight loss is completely wrong
• Time to Correctly Predict the Amount of Weight Loss With Dieting
• Mysteries of Weight Loss
• The energy balance model of obesity: beyond calories in, calories out
• “Calories in, calories out” and macronutrient intake
• Olympians owe gold standard to a 19th-century chemist
• Calories on food packets are wrong—it’s time to change that
• Why Does the FDA Recommend 2,000 Calories Per Day?
• Who Actually Needs a 2,000 Calorie a Day Diet?
• The Nutrition Facts Label: Its History and Updates

Thanks to Doctor Dreamchip for our lovely theme song!