Expert interventional pulmonologists and medical oncologists discuss the management of malignant pleural effusion, airway obstruction, and immune-related pneumonitis during the COVID-19 pandemic. The panelists review the literature on these topics and share their own personal and institutional experiences. (Originally recorded June 10, 2021) Moderator: Septimiu Murgu, MD, FCCP. Panelists: Mary Jo Fidler, MD; David Feller-Kopman, MD, FCCP; and Eric Edell, MD, FCCP. For more tools to help in the fight against COVID-19, visit CHEST’s COVID-19 Resource Center at chestnet.org/COVID19.