#024: Shawn Wells #3 | BAIBA (β-Aminoisobutyric Acid) - Weight Loss Ingredient Mimics Exercise?!
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We’re always on the lookout for supplement ingredients that could be the “Next Big Thing”, and it’s very possible we just found one for dieters.

Its name is BAIBA (pronounced “BAY-buh”), and it may be able to mimic certain fat-burning processes that occur in your body when exercising – even when you’re not working out!

Of course, we never suggest avoiding exercise, but research published in 2014 definitely got our attention, which is why we originally wrote this article in 2015. Four years later, we finally found a trustworthy ingredient supplier in NNB Nutrition’s MitoBurn, allowing us to pursue more research.


  • BAIBA (or β-aminoisobutyric acid) is an “amino acid” generated during exercise.
  • It is involved in several healthy processes, such as the thermogenic browning of white fat and exercise-based prevention of bone and muscle loss.
  • When supplemented, it is pro-ketogenic and increases fatty acid oxidation in the liver while protecting against fat gain and improving glucose tolerance in mice. (See the BAIBA Research section)
  • There are two isomers of BAIBA, L-BAIBA and D-BAIBA, research shows L-BAIBA is superior for supplementation because it leads to more positive metabolic health outcomes.
  • The preferred BAIBA Supplement ingredient is MitoBurn by NNB Nutrition. (See the BAIBA Supplements section)
    • Suggested doses are 250-500mg, 1-2 times per day. (See the BAIBA Dosage section)
  • There are no currently known side effects at the above doses, but because it is a new ingredient with limited human research, caution is suggested.
  • In 2019, safety data was conducted on mice and showed L-BAIBA’s LD50 (lethal dose for 50% of animals) was well over 2,000mg/kg of body weight, which means we’re very comfortable with the suggested dose.
  • Under DSHEA, BAIBA is by definition a dietary supplement since it covers several sections.

No statements on this page are approved by the FDA and you should seek a doctor’s approval before beginning any new supplement or dietary program.

This article was originally written in 2015, but updated in 2019 after finally finding a reputable raw material source from NNB Nutrition.

This ingredient is incredibly interesting, especially to aggressive dieters, but is definitely not for the conservative or cautious user — at least until more human-based research is published.

This article is science-intense, so get ready:

What is BAIBA?

BAIBA, or β-aminoisobutyric acid, is an amino acid generated during exercise (an “exercise-induced muscle factor”) that is not naturally found in the genetic code of any organism — it’s formed when either thymine or valine are broken down.

This means that BAIBA, while an amino acid, is not a building block for proteins but rather is used as a signaling molecule within the body. Because of this, consuming it will not contribute to the development of muscle mass like traditional essential amino acids (often used for recovery during or after a workout), but it may hold promise for fat-loss – and weight loss.

  • L-BAIBA vs. D/R-BAIBA: Which Form is Best?

    There are two forms of BAIBA discussed in the literature: L-BAIBA (S-BAIBA) and D-BAIBA (R-BAIBA). These two types are also referred to as enantiomers, which means they’re a pair …

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