Computationally Yours
Sabah Kadri and Arshi Arora
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(n-1) things to explore and discuss about Computational Biology. Join us as we converse about everything computational in the biomedical sciences and beyond. #accessibleScience
Available episodes
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6 days ago
Episode 12: Clinical Practitioners of Precision Medicine
In this episode, hosts, Dr. Sabah Kadri and Arshi Arora ask leading experts in Molecular Pathology across clinical laboratories across the United States, their personal experience with Precision Medicine, its effect on their clinical practice as well as their views of the future of personalized medicine. Ours guests for this episode are:
Dr. Rashmi Kanagal-Shamanna, Hematopathologist, Molecular Genetic Pathologist, Associate Professor at MD Anderson Cancer Center
Dr. Mark Ewalt, Hematopathologist at Memorial Sloan Kettering
Dr. Alanna Church, Associate Director, LaMPP at Boston Children's Hospital Assistant Professor of Pathology, Harvard Medical School
Dr. Joshua Coleman , Assistant Professor of Pathology at the University of Utah and Medical Director at ARUP Laboratories
Dr. Kailee Yap, Director of Molecular Diagnostics, Assistant Professor of Pathology from Lurie Children’s hospital
Dr. Somak Roy, Assistant Professor and Molecular Pathologist, The University of Pittsburgh Medical Center
Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com
Follow us on Twitter: @compbiopodcast ; Dr. Sabah Kadri: @sabahkadri ; Arshi Arora: @arorarshi
Intro/Outro music: Riatsu (Shadaab Kadri)
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Thumbnail image: Pixabay Public Domain Picture --- Send in a voice message: https://anchor.fm/computationally-yours/message
Jul 21, 2020
Episode 11: Precision Medicine 101
Did you know there was a time when no one knew about blood groups so no one knew to check the blood group of a donor before transfusion? There was also a time when a patient's treatment could not be tailored to their DNA changes. But none of that happens today. Do you know why? And do you know how? Listen to Dr. Sabah Kadri break down precision medicine and its revolutionary effects on patient care in this extremely engaging episode. We take an anecdote-filled roller coaster from the 1800s to 2020. Enjoy the ride!
Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.
Follow us on Twitter: @compbiopodcast ; Dr. Sabah Kadri: @sabahkadri ; Arshi Arora: @arorarshi
Follow us on Instagram here.
Original Intro/Outro music: Riatsu (Shadaab Kadri)
References:
* What is personalized medicine: sharpening a vague term based on a systematic literature review: _https://pubmed.ncbi.nlm.nih.gov/24359531/
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* Jones DS. How personalized medicine became genetic, and racial: Werner Kalow and the formations of pharmacogenetics. J Hist Med Allied Sci. 2013;68(1):1-48. doi:10.1093/jhmas/jrr046
* _https://www.acc.org/latest-in-cardiology/articles/2018/10/14/12/42/harold-on-history-the-evolution-of-personalized-medicine
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* _https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet
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* _https://www.cancer.gov/about-cancer/treatment/clinical-trials/search
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* Hugo A. Barrera-Saldaña, Origin of personalized medicine in pioneering, passionate, genomic research,Genomics, Volume 112, Issue 1, 2020
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Jul 14, 2020
Episode 10: Know Your Hosts
Our hosts, Dr. Sabah Kadri and Arshi Arora are women in science celebrating a friendship that spans over a decade. In this episode, we get up-close and personal to get to know our hosts, their journeys in science and the hardships along the way. They discuss what excites them about science (Spoiler alert: it's everything), an embarrassing revelation and advice for young scientists starting out in the field. Join us in getting to know the people who bring you Computationally Yours.
Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.
Follow us on Twitter: @compbiopodcast ; Dr. Sabah Kadri: @sabahkadri ; Arshi Arora: @arorarshi
Intro/Outro music: Riatsu (Shadaab Kadri)
Follow us on YouTube here.
Follow us on Instagram here. --- Send in a voice message: https://anchor.fm/computationally-yours/message
Jul 7, 2020
Episode 9: The inspiring story of Barbara McClintock
In our first "Profiles in Scientific Genius" series, we discuss the inspiring story of Dr. Barbara McClintock (1902-1992), the first woman to have received a solo Nobel Prize in Physiology or Medicine. Achieving success against all odds, her story will make you believe. Dr. Sabah Kadri and Arshi Arora peek into her childhood, her support system, the odds she faced when she wanted to research in genetics at a time that women were not accepted into that department, and her eventual triumph in the field.
Link to National Academy of Science: http://www.nasonline.org/publications/biographical-memoirs/memoir-pdfs/mcclintock-barbara.pdf
Research Review: https://www.pnas.org/content/109/50/20198
Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.
Follow us on Twitter: @compbiopodcast ; Dr. Sabah Kadri: @sabahkadri ; Arshi Arora: @arorarshi
Intro/Outro music: Riatsu (Shadaab Kadri)
Follow us on YouTube here.
Follow us on Instagram here.
Photo from Cold Spring Harbor.
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Jun 30, 2020
Episode 8: What makes us different and the same: Genetic Variation
Our DNA makes us unique. It also makes us similar to each other - sometimes more and sometimes less. How? Dr. Sabah Kadri and Arshi Arora explore similarities and differences in our DNA. And in the process, they discuss milestone genomics projects in human beings such as dbSNP, the HapMap project and Genome Wide Association Studies. They look at studies all the way from one that looks at genetic factors involved in Covid-19 to one that investigates the genetics of curly hair. This one is a fun ride.
Link to papers discussed:
GWAS Covid study:
_https://www.nejm.org/doi/full/10.1056/NEJMoa2020283_
Biology and genetics of curly hair:
_https://onlinelibrary.wiley.com/doi/full/10.1111/exd.13347_
GWAS and HapMap
_https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717504/_
Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.
Follow us on Twitter: @compbiopodcast ; Dr. Sabah Kadri: @sabahkadri ; Arshi Arora: @arorarshi
Intro/Outro music: Riatsu (Shadaab Kadri)
Follow us on YouTube here.
Follow us on Instagram here.
Thumbnail from Pixabay. Thanks to @eliaas.sch --- Send in a voice message: https://anchor.fm/computationally-yours/message
Jun 23, 2020
Episode 7: (Not so) Junk DNA
Next stop on the Genomics train is Junk DNA - the non-coding part of the genome. Dr. Sabah Kadri does a deep dive into the parts of the genome that we are still trying to understand. She highlights the major milestones in the field, its achievements and challenges, peppered with the usual origin stories and fun anecdotes from scientific history.
Links to papers in the episode:
Susumo Ohno: http://www.junkdna.com/ohno.html
Studies on functions of non-coding DNA: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447085/, https://www.nature.com/articles/s41588-019-0420-0
Functional definition and its controversy: https://www.journals.uchicago.edu/doi/full/10.1086/676588
A fun read: https://science.sciencemag.org/content/263/5147/608
Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.
Follow us on Twitter: @compbiopodcast ; Dr. Sabah Kadri: @sabahkadri
Intro/Outro music: Riatsu (Shadaab Kadri)
Follow us on Instagram here.
Follow us on YouTube here.
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Jun 16, 2020
Episode 6: Microbial Genomics
Ever wonder what it is like to study the genomics of microbes likes bacteria and viruses? Dr. Sabah Kadri talks with Dr. Egon Ozer about the field of microbial genomics, the relatively fast evolution of microbes and the study from Dr. Ozer's group studying the genomic sequences of SARS-CoV-2, the virus in the COVID-19 pandemic. Tune in as we learn about this field, its challenges and methodologies.
Link to paper discussed: https://www.medrxiv.org/content/10.1101/2020.05.19.20107144v1
Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.
Follow us on Twitter: @compbiopodcast ; Dr. Sabah Kadri: @sabahkadri ; Arshi Arora: @arorarshi
Intro/Outro music: Riatsu (Shadaab Kadri)
Follow us on YouTube here.
Follow us on Instagram here. --- Send in a voice message: https://anchor.fm/computationally-yours/message
Jun 9, 2020
Episode 5: Human Genome Project
Dr. Sabah Kadri and Arshi Arora discuss the landmark project that changed genomics and bioinformatics forever: The Human Genome project. They discuss the what, why and how as well as the interesting stories that mark the journey of the human genome.
Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.
Follow us on Twitter: @compbiopodcast ; Dr. Sabah Kadri: @sabahkadri ; Arshi Arora: @arorarshi
Intro/Outro music: Riatsu (Shadaab Kadri)
Follow us on YouTube here.
Follow us on Instagram _https://www.instagram.com/computationallyours/_
Website: _http://computationallyyours.netlify.app/_ --- Send in a voice message: https://anchor.fm/computationally-yours/message
May 26, 2020
May 26th: Announcement
Instead of a full episode, we have a quick announcement about what is to come in the month of June! This is so exciting.
Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.
Follow us on Twitter: @compbiopodcast ; Dr. Sabah Kadri: @sabahkadri ; Arshi Arora: @arorarshi
Intro/Outro music: Riatsu (Shadaab Kadri)
Follow us on YouTube here.
Follow us on Instagram _https://www.instagram.com/computationallyours/_
Website: _http://computationallyyours.netlify.app/_ --- Send in a voice message: https://anchor.fm/computationally-yours/message
May 19, 2020
Episode 4: Clinical Trials for Infectious diseases
Infectious disease expert, Dr. Andrew Trotter discusses clinical trials in infectious diseases with Dr. Sabah Kadri and Arshi Arora in this episode of Computationally Yours. This is Part 2 in a 2-part series on clinical trials. We dive into what makes clinical trials in infectious diseases or conducting trials for vaccines different, and the importance of participation of patients in these trials. This episode makes complex concepts simple and approachable #accesibleScience
Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.
Follow us on Twitter: @compbiopodcast ; Dr. Sabah Kadri: @sabahkadri ; Arshi Arora: @arorarshi
Intro/Outro music: Riatsu (Shadaab Kadri)
Follow us on YouTube here.
Follow us on Instagram _https://www.instagram.com/computationallyours/_
Website: _http://computationallyyours.netlify.app/_ --- Send in a voice message: https://anchor.fm/computationally-yours/message
May 12, 2020
Episode 3: Clinical Trials 101
Dr. Sabah Kadri and Arshi Arora discuss the basics of clinical trials and give the listeners a fun 101 course on how trials are designed and some fundamental concepts of the process. You do not need to be an expert in Science to learn about Clinical Trials with us #accessibleScience
Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.
Follow us on Twitter: @compbiopodcast ; Dr. Sabah Kadri: @sabahkadri ; Arshi Arora: @arorarshi
Intro/Outro music: Riatsu (Shadaab Kadri)
Follow us on YouTube here.
Follow us on Instagram here. --- Send in a voice message: https://anchor.fm/computationally-yours/message
May 11, 2020
Episode2: Contact Tracing
In our second episode, Dr. Nicholas Soulakis breaks down Contact Tracing for our listeners and discusses the role of data and computational modeling in the contact tracing program. Dr. Soulakis is a career epidemiologist currently supporting the contact tracing program for the Illinois Department of Public Health. #accessibleScience #contactTracing
Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com
Follow us on Twitter:
Computationally Yours Official Account: @compbiopodcast
Dr. Sabah Kadri: @sabahkadri
Arshi Arora: @arorarshi
Intro/Outro music: Riatsu (Shadaab Kadri)
Follow us on YouTube here. --- Send in a voice message: https://anchor.fm/computationally-yours/message
Apr 28, 2020
Episode1: Hello World
The very first episode of our podcast. Get to know us a little, why we started this podcast and find out what happens when we assign ourselves the task to learn about the origins of Computational Biology.
Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.
Follow us on Twitter:
Computationally Yours Official Account: @compbiopodcast
Dr. Sabah Kadri: @sabahkadri
Arshi Arora: @arorarshi
Intro/Outro music: Riatsu (Shadaab Kadri)
Follow us on YouTube here.
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Send in a voice message: https://anchor.fm/computationally-yours/message