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Dr. Yamina Berchiche
We bring you closer to dedicated scientists who work tirelessly to help understand GPCR pathophysiology.
22 hours ago
Episode #15 How two isoforms of beta-arrestin can regulate the function of GPCRs?
In this episode of the Dr.GPCR podcast, my guest is Dr. Arun Shukla from the Indian Institute of Technology in Kanpur, India. Arun is currently an Associate Professor & Joy Gill Chair Professor, Intermediate Fellow, Wellcome Trust DBT India Alliance Swarnajayanti Fellow & EMBO Young Investigator at the Department of Biological Sciences and Bioengineering. He earned his master's degree in biotechnology from Jawaharlal Nehru University in India and it was during a biochemistry class where he learned about cell signaling that he became curious and wanted to learn more about it. Arun first started working on GPCRs and their structural characterization at the Max Planck Institute of Biophysics where he completed his doctoral studies in the lab of Dr. Hartmut Michel. Fascinated by GPCRs he wrote to Dr. Bob Lefkowitz and asked him if he could join his lab at Duke University. Dr. Shukla spent several years in the Lefkowitz lab and collaborated extensively with Dr. Brian Kolbika of Stanford University. Join us and learn more about Dr. Shukla’s research and how working in the lab instead of going to classes made him realize that research is what he wants to do for the rest of his life.
Oct 20, 2020
Episode #14 Creating better psychiatric medications
Dr. Bryan Roth is the Michael Hooker Distinguished Professor of Pharmacology at the University of North Carolina Chapel Hill School of Medicine. After receiving his MD and Ph.D. in Biochemistry from St. Louis University in 1983, he subsequently trained in pharmacology (NIH), molecular biology, and psychiatry at Stanford. Bryan leads a $26.9 Million project to create better psychiatric medications among other things. But, it wasn’t always this way. Bryan got fascinated with receptors after attending the lecture of a visiting professor on neurotransmission while in college in Montana, where he is from. He was determined to work on psychiatric disorders and persevered even when he was told several times he would never make it as a basic scientist and that he would never publish anything important. Join me and learn more about Bryan and his work.
1 hr 13 min
Oct 8, 2020
Episode #13 Migraine and the promising role of DOR as a therapeutic target for headache with Dr. Amynah Pradhan
In this episode of the Dr. GPCR podcast, we meet with Dr. Amynah Pradhan. She is an Associate Professor of Psychiatry at the University of Illinois at Chicago. Amynah did her undergrad research measuring IP3 in airway smooth muscle cells and completed a Ph.D. at McGill University in Canada with Dr. Paul Clarck where she studied opioid receptors. Her next career step took her to AstraZeneca as a postdoctoral trainee where she studies animal models of pain and sensory neuron sensitive-receptor. She then moved back to academia and worked on opioids as a postdoctoral trainee with Dr. Brigitte Kieffer where she studied ligand directed signaling at the delta-opioid receptor. Her career path defining moment came from a third postdoctoral experience with Dr.Chris Evans at UCLA. Amynah studied how arrestins regulate ligand directed signaling at delta-opioid receptors and it is the collaboration with a headache physician-scientist Dr. Andrew Charles that she specialized in animal models of migraine and delta-opioid receptors as a therapeutic target to treat a headache.
1 hr 10 min
Sep 29, 2020
Episode #12 Using computational pharmacology to understand chemosensory GPCR function with Dr. Antonella Di Pizio
In this episode of the Dr. GPCR podcast, we meet with Dr. Antonella Di Pizio, an independent research group leader at the Leibniz-Institute for Food Systems Biology at the Technical University of Munich. Antonella trained as a medicinal chemist in Italy, which she followed up by a Ph.D. in computational medicinal chemistry, during which she developed a taste for structural biology. Antonella then moved to Israel, where she first started working on bitter taste GPCRs in Dr. Masha Niv's lab. Today, Antonella has expanded her research to olfactory GPCRs and trace amine receptors. Join us to learn more about chemosensory GPCRs and how computational pharmacology can help better understand their function.
1 hr 9 min
Sep 16, 2020
Episode #11 Genemod: making research efficient and reproducible
In this special episode of the Dr.GPCR podcast, I sat down with the co-founders of Genemod. Jacob Lee and Jin Choe met in ninth grade in English class and have been friends since. Although both went to the same college, Jacob and Jin choose different career paths. One day as they were catching up, Jacob shared his struggles of managing samples and an incredible amount of data and projects in the lab with Jin. Our of this need Genemod was born. Today, Genemod has built a freezer management tool and a project management tool where scientists can manage their reagents, samples, and projects on one intuitive platform. The team is planning on building even more tools that will make Genemod the go-to platform for all research scientists to make research more efficient.
Sep 12, 2020
Episode #10 Novel signaling regulators of opioid receptors with Dr. John Streicher
Our guest in this episode of the Dr.GPCR podcast is Dr. John Streicher from the department of pharmacology at the University of Arizona. John started grad school in 1999 and spent some time figuring out what he was interested in. It turns out that it was signal transduction and he worked on the signaling cascades involved in heart failure. His encounter and interest in signaling in the context of GPCRs during his postdoctoral training in Dr. Laura Bohn’s lab at Scripps Research Institute in Florida. Today, John and his team focus on understanding how signal transduction cascades downstream of the opioid receptors work.
1 hr 9 min
Sep 3, 2020
Episode #9 Exploring your career options
In this special Dr. GPCR podcast episode, we sat down to chat with Lauren Celano to talk about career options for Ph.D.’s. Working in a lab allows scientists to gain amazing hard and soft skills, which opens the doors to a number of great careers, that many have not even considered, yet. Lauren has a science background and is passionate about helping talented scientists find their dream position. She is also a speaker, connector, recruiter, and coach.
Aug 23, 2020
Episode #8 R&D in the Time of Covid-19 with Dr. Graciela Pineyro
Dr. Graciela Pineyro is a professor of pharmacology at the department of pharmacology and physiology of the University of Montreal. She has done extensive work on the molecular pharmacology of opioid receptors and is currently focusing on the pharmacology of cannabinoids in the context of pain. We chatted about how the current pandemic has affected her personally and professionally.
Aug 23, 2020
Episode #7 Armchair science in the time of Covid-19 with Dr. Paul Insel
Dr. Paul Insel is currently a Distinguished Professor of Pharmacology and the University of California San Diego. Paul thinks broadly about science and has been actively publishing papers about his ideas on how COVID symptoms could be treated while we wait for a vaccine, particularly about ACE2 and angiotensin. For the past 30 years, he has been the Director of MD/Ph.D. training program at UCSD and has served as Editor or Senior Editor of numerous scientific journals, including but not limited to the Journal of Clinical Investigation, Molecular Pharmacology, British Journal of Pharmacology, and American Journal of Physiology-Cell Physiology.
Aug 22, 2020
Episode #6 R&D in the Time of Covid-19 with Dr. J. Silvio Gutkind
Dr. J. Silvio Gutkind sheds light on his work and life since the beginning of COVID restrictions. Dr. J. Silvio Gutkind is a Professor of Pharmacology based at UCSD School of Medicine. A large component of his work is centered around dysregulated signaling in cancer and the development of novel mechanism-based cancer therapies. In this episode, Dr. J. Silvio Gutkind highlights how his past experience proves useful in current COVID times and potential benefits the changes in work environments can do for future collaborations.
Aug 22, 2020
Episode #5 R&D in the Time of Covid-19 with Dr. Terry Hébert
Dr. Terry Hébert is a Professor within the Department of Pharmacology & Therapeutics at McGill University. Much of his work is based around GPCR signaling in context to cardiovascular diseases. In this special episode of the Dr.GPCR podcast, we re-connected with Dr.Terry Hebert to chat about how he and his team has been adapting to the new reality of working remotely. Terry tells us about the importance of adapting, communication, and being mindful of those around us.
Jul 21, 2020
Episode #4 Not everything is Black and White: G-proteins vs β-arrestins
Dr. Graciela Pineyro’s love for GPCR pharmacology started in Uruguay where she first worked on the serotonin receptors. This interest in research and pharmacology took Graciela to Canada where she stayed ever since she arrived for her Ph.D. work. Graciela has done extensive work on the molecular pharmacology of opioid receptors, exploring their signaling, trafficking, and their ability to activate different signaling pathways and signaling bias. Today, Graciela and her team’s efforts are directed towards the characterization of the pharmacological properties of cannabinoids in conjunction with terpenes for pain relief.
Jul 2, 2020
Episode #3 GPCR signaling in cancer with Dr. J. Silvio Gutkind
Have you had moments that defined your scientific tastes? For Dr. J Silvio Gutkind, a class on oncogenes and his interests for GPCRs helped shape his scientific interests. These took him from the University of Buenos Aires in Argentina to UC San Diego and through the National Institutes of Health in Bethesda, Maryland. In this episode, Silvio discusses G protein signaling in the context of cancer, immunotherapies, and combination therapies that could help improve patients’ lives.
1 hr 1 min
Jun 17, 2020
Episode #2 How cellular background and localization influence GPCR function
Dr. Terry Hebert wanted to be a microbiologist. Instead, he ended up getting interested in membrane protein as he followed the biology of a bacterial toxin that affects a mammalian ion channel. Today he and his team are working on understanding receptor signaling in specialized cellular environments to gain a better grasp of receptor function in pathophysiological settings with a special interest in the cardiovascular system. His favorite GPCR is the angiotensin 1 receptor especially for its ability to activate a large variety of signaling pathways. Terry is also very active on social media. With over 2000 followers on Facebook and Twitter, he shares the latest available information on GPCR research daily.
Jun 2, 2020
Episode #1 How thinking broadly leads to significant scientific discoveries
In 1975, Dr. Paul Insel was at the FASEB experimental biology meeting in Atlantic City. During dinner with colleagues and Alfred Gillman, co-recipient of the 1994 Nobel Prize in Physiology or Medicine for their discovery of G-proteins and their role in signal transduction in cells, Paul was designated to go to Gillman’s lab. That summer, he used radioligand binding methods to dissect receptor function from the adenylyl cyclase activated by ligands, including adrenaline. From that point on, Paul was hooked and has since studied receptor function in human physiology, receptor molecular pharmacology in cells, and animal models, and as he puts it has now he’s ‘’gone full circle’’ back to studying GPCRs important in human pathophysiology. Today, Paul and his team focus on previously unrecognized receptors with the hopes to use these as novel drug targets.
May 12, 2020
Episode #0 Dr. GPCR Podcast
In this Episode 0 of the podcast, I, Dr. Yamina Bechiche, your host, and founder of DrGPCR introduce you to the very first podcast dedicated to GPCR researchers and their work. This podcast is part of the Dr. GPCR Ecosystem. The goal is to bring us together GPCR scientists, biotech, and pharma leaders as well as suppliers working on GPCRs. We want to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together to accelerate GPCR drug discovery and improve human health. For more information visit us at DrGPCR.com/Podcast and join the DrGPCR Ecosystem at DrGPCR.com/Ecosystem. Don't forget to subscribe to our monthly newsletter at DrGPCR.com/Newsletter.