Acute pain is associated with negative outcomes, and efforts to prevent and control pain are necessary. Goals for acute postoperative pain management include reducing the incidence and severity of pain, particularly that which impacts patient function such as movement. Also important is minimizing side effects from analgesics, preventing postoperative complications, enhancing recovery, and preventing chronic pain if possible. The purpose of this session will be to discuss common challenges including pain assessment, opioid safety, and individualizing multimodal analgesia. Patient cases will be used to illustrate decision making when applying basic principles of multimodal treatment to perioperative treatment plans.