Chronic pain affects 100 million US adults. It is the #1 reason people are out of work. It is the leading reason that people seek medical attention, costing the nation upwards of $635 billion annually--more than heart disease, cancer, and diabetes combined. Given the burden of unmanaged pain in terms of human suffering, societal burden, and healthcare dollars spent, relieving pain has become a national priority. This case based lecture will define the pathophysiology of various pain generators, and provide a comprehensive overview of multimodal management of chronic/persistent and acute pain. The use of pharmacotherapy, nerve blocks, and behavioral management strategies will be emphasized. This lecture will examine the decision making involved in developing a treatment strategy for patients with complex pain diagnosis. Special emphasis will be placed on cancer pain, the patient with an addiction history, central pain, and neuropathic pain.