Central pain conditions are difficult to treat. What is worse, many central pain conditions are misdiagnosed or mistreated. Conditions such as depression, anxiety, trigeminal neuralgia, complex regional pain syndrome (CRPS), various neuropathies, phantom limb pain, postherpetic neuralgia, fibromyalgia, PTSD, and others can be very responsive to ketamine infusions. There have been many infusion protocols out there with variable results. We will discuss various conditions, the infusion, and the results we have seen.