Dr. Manny Villafana is one of the most successful men in the history of medical innovation, having founded four companies, including CPI/Guidant Corp. and St. Jude Medical, Inc. His most recent venture, Kips Bay Medical was supposed to be his best work yet. However, problems with the FDA and shortfalls on funding doomed the company, which shut down in September 2015. Recorded live on September 23rd at DeviceTalks Minnesota, just one day after he resigned as CEO of Kips Bay Medical, we discuss failure with Dr. Villafana. How does someone who has had so much success deal with the opposite? What comes next for this serial entrepreneur?