Dec 27, 2021
HPV-independent Cervical Cancers with Andreina Fernandes
In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez, is joined by Dr. Andreina Fernandes to discuss HPV-independent Cervical Cancers. Dr. Fernandes is a Molecular Biologist, Doctor of Science, and author of “Human papillomavirus-independent cervical cancer,” the Lead Article for the January 2022 issue of IJGC. Dr. Fernandes is a Researcher of the Molecular Genetics Laboratory at the Institute of Oncology and Hematology, and Professor of the Faculty of Dentistry, at Universidad Central de Venezuela in Caracas, Venezuela. (https://ijgc.bmj.com/content/early/2021/12/08/ijgc-2021-003014) Highlights: -The percentage of HPV-independent tumors is very variable, around 5 and 10%. -HPV-independent tumors are characterized by a differentiated molecular profile with lower proliferative activity, a p53 immunostaining, and alterations in PTEN, p53, KRAS, CTNNB1, ARID1A and ARID5B. -Most HPV-independent tumors are adenocarcinomas, however, there have been reports of HPV-indepe…